The Wyeth and Wythe Families of America. Seven Generations of the Descendants of Nicholas WyethThe Wyeth Wythe family is American history in action. The family has been on the forefront of the American story since Nicholas Wyeth came to the Massachusetts Bay Colony around the time of the Great Migration. They struggled through King Philip's War, suffered cruelly in the Salem Witch Trials, protested taxation without representation in the Boston Tea Party, marched as minutemen on the first day of the American Revolution, served in General George