Probio Mood SAPProbiotics for mood balance (science based) Extensive research on the gut brain axis has revealed bidirectional communication between the gut and brain, facilitated by microbial flora. The gut microbiota has been proven to play an important role in digestive disorders, skin diseases and immune function. Recent clinical trials have shown that specific strains of Lactobacillus and Bifidobacterium are able to regulate mood imbalances, stress and anxiety.