Berberine SAP 300mgBerberine for optimal metabolic function (science based) Berberine is an active constituent found in a variety of plant species. More recent studies have shown that berberine has biological effects on multiple pathways in the body, indicating that it may be a potential treatment for metabolic syndrome. Metabolic syndrome is thought to begin with an accumulation of lipids in nonadipose tissues, known as nonalcoholic fatty liver disease (NAFLD).