Hydrogen Sulfide and its Therapeutic ApplicationsThe metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900s. Three enzymes, cystathionine ?synthase (CBS), cystathionine ?lyase (CSE) and 3 mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active
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